Hypertriglyceridemia is positively correlated with the development of colorectal tubular adenoma in Japanese men

瞄准：决定在浆液类脂化合物层次和结肠的息肉形成之间的真实协会。方法：我们执行了大规模分析在表面的腺瘤或癌和禁食浆液在为为结肠癌屏蔽经历了全部的结肠镜检查的病人全部的胆固醇(TC ) 和 triglycerides (TG ) 铺平的肤色的发生之间的关联的回顾的学习。结果：没有任何肿瘤的损害，两水平显著地作为与病人相比与腺瘤在病人被提高(TC 207.6+/-29.5 对 199.5+/-34.3， n=4883， P【0.001；TG 135.0+/-82.2 对 108.7+/-71.5， n=4874， P【0.001 ) 。差别在有管状腺瘤然而并非在那些与的病人是重要的覆有一层绒毛或 serrated 腺瘤。包括年龄和性别的多重逻辑回归分析表明 TG 是在男性(P【0.01 ) ，然而并非在女病人的一个独立关联因素。在有侵略的癌的病人的 TG 的水平没与腺瘤在病人从那显示出重要举起。这些调查结果建议 hypertriglyceridemia 是为在人的结肠的腺瘤的一个独立风险因素。结论：尽管浆液甘油三酸酯的高水平不看起来机械地涉及癌的发展，有全部的结肠镜检查的浆液 TG 和集中的监视的减小可以与 hypertriglyceridemia 在人有利益。

AIM： To determine the real association between serum lipid levels and colonic polyp formation. METHODS： We performed a large scale retrospective study to analyze the correlation between the incidence of colorectal adenoma or carcinoma and the fasting serum levels of total cholesterol （TC） and triglycerides （TG） in patients who underwent total colonoscopy for screening for colon cancer. RESULTS： Both levels were significantly elevated in patients with adenomas as compared with patients without any neoplastic lesion （TC 207.6 ± 29.5 vs 199.5 ±34.3, n= 4883, p〈 0.001; TG 135.0 ± 82.2 vs 108.7± 71.5, n= 4874, p〈 0.001）. The difference was significant in patients with tubular adenoma but not in those with villous or serrated adenoma. Multiple logistic regression analysis including age and sex revealed that TG was an independent correlation factor in male （p〈0.01）, but not in female patients. The level of TG in patients with invasive carcinoma did not show a significant elevation from that in patients with adenoma. These findings suggest that hypertriglyceridemia is an independent risk factor for colonic adenoma in men. CONCLUSION： Although a high level of serum triglyceride does not appear to be mechanically involved in the development of carcinoma, reduction of serum TG and intensive surveillance with total colonoscopy may have benefit in men with hypertriglyceridemia.