Does endothelium agree with the concept of idiopathic hepatic vessel thrombosis?

瞄准：为了调查血栓形成的主要的步并且在这些识别差别，走在自发的耐心的组和控制组之间。方法：Fibrinogenesis 被测量激活的第七因子，总数和织物因素小径禁止者(TFPI ) 的免费层次学习。纤维蛋白溶解作用步被决定全球 fibrinolytic 能力调查。内皮功能被测量可溶的粘附分子的层次估计，也就是可溶的细胞间的粘附分子 1 (sICAM-1 ) ，可溶的脉管的房间粘附分子 1 (sVCAM-1 ) 并且可溶的 E-selectin 分子。从“自发”的耐心的组的排除标准是腹的外科，怀孕，口服避孕药的使用， anti-phospholipid 症候群， Behcet 的疾病，癌症， myeloproliferative 疾病。先天的因素喜欢 factor-V Leiden 的变化，凝血素，蛋白质 C 和 S 的缺乏，反凝血酵素， hyperhomocysteinemia 和 hyperfibrinogenemia 被排除。病人的全部的数字从 96 ～ 9 被减少(7 与门静脉血栓， 2 Budd Chiari 症候群) 由排除标准。结果：粘附分子 sICAM-1， sVCAM-1，免费 TFPI 层次和全球 fibrinolytic 能力的层次是显著地不同的(P【0.05 ) 在耐心的组显示一个内皮机能障碍和一项更低的 fibrinolytic 活动。结论：这些结果证明这个耐心的组应该借助于内皮机能障碍被测试并且不同地设法。

AIM： To investigate the major steps of thrombogenesis and to identify the differences in these steps between idiopathic patient group and control group. METHODS： Fibrinogenesis was studied by measuring the activated factor Ⅶ, total and free levels of tissue factor pathway inhibitor （TFPI）. The fibrinolysis step was investigated by determining the global fibrinolytic capacity. The endothelial function was assessed by measuring the levels of soluble adhesion molecules, namely soluble intercellular adhesion molecule 1 （sICAM-1）, soluble vascular cell adhesion molecule 1 （sVCAM-1） and soluble E-selectin molecule. The exclusion criteria from ＂idiopat- hic＂ patient group were abdominal surgery, pregnancy, use of oral contraceptives, anti-phospholipid syndrome, Behet＇s disease, cancer, myeloproliferative diseases. The congenital factors like mutations of factor-Ⅴ Leiden and prothrombin, deficiencies of proteins C and S, antithrombin, hyperhomocysteinemia and hyperfibrinogenemia were ruled out. The total number of patients was reduced from 96 to 9 （7 with portal vein thrombosis, 2 Budd Chiari syndrome） by exclusion criteria. RESULTS： The levels of adhesion molecules sICAM-1, sVCAM-1, free TFPI levels and global fibrinolytic capacity were significantly different （P〈 0.05） in the patient group indicating an endothelial dysfunction and a lower fibrinolytic activity. CONCLUSION： These results show that this patient group should be tested by means of endothelial dysfunction and managed differently.