摘要
目的研究胃癌人表皮生长因子受体(HER)-2/neu基因的表达与生存期的关系,探讨其作为胃癌预后指标的可行性。方法应用免疫组织化学方法检测103例胃癌标本HER-2/neu基因的表达,并将检测结果与患者的随访资料及临床病理参数进行综合分析。结果103例胃癌组织中HER-2/neu基因的阳性表达率为31.1%(32/103);HER-2/neu基因在胃良性病变和癌旁组织中均无表达;HER-2/neu基因表达与患者的性别、年龄、肿瘤大小、部位、分化程度均无相关性(P>0.05),而与肿瘤的浸润深度、临床分期、淋巴结转移、远处转移及患者的生存时间相关(P<0.05)。结论HER-2/neu基因与胃癌的浸润、转移及预后密切相关,可作为判断胃癌生物学行为和预后的重要参考指标。
Objective To investigate the association between the expression of human epidermal growth factor receptor （HER） -2/neu gene and prognosis of gastric cancer. Methods The expression of HER-2/neu in gastric cancer was detected by immunohistochemical technique and analyzed in relation with the follow-up and clinicopathologic data of the patients. Results Thirty-two of the 103 gastric cancer specimens （31.1%） were positive for HER-2/neu, but whose expression was not found in benign gastric lesion and normal gastric mucosa. HER-2/neu expression was not correlated with the patients＇ sex, age, tumor size and location or the degree of differentiation （P〉0.05）, but with the depth of invasion, clinical stage, lymph node and distant metastasis of the tumor and survival of the patients （P〈0.05）. Conclusion HER-2/neu expression is closely related to invasion, metastasis and prognosis of gastric cancer and can be used to evaluate the biological behavior and prognosis of gastric cancer.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2006年第3期344-347,共4页
Journal of Southern Medical University
