摘要
目的:探讨胃癌组织钙粘蛋白的表达与癌淋巴道转移的相关性。方法:取胃癌标本14例,正常胃组织标本2例。通过E-cadherin、β-catenin和LYVE-1免疫组化方法,观察肿瘤淋巴管的表达。结果:LYVE-1在正常和癌组织淋巴管阳性表达,正常淋巴管E-cadherin、β-catenin表达阴性,β-catenin在胃癌淋巴管表达弱阳性,β-catenin在淋巴管的表达与肿瘤的分化程度及有无转移有负相关性。结论:LYVE-1在淋巴管特异性表达,E-cadherin/β-catenin复合物在淋巴道转移过程中,对肿瘤细胞与淋巴管内皮细胞的粘附起一定的作用,但不是主要作用。
Objective： To discuss the expression of cadherin in gastric carcinoma and explore its relation with the mechanism of lymphatic metastasis. Mothods： 14 gastric carcinoma specimen and 2 normal stomach specimen were adopted. Expressions of E-cadherin,β-catenin and LYVE-1 on lymphatic vessels of above samples were detected by immunohistochemical method. Results： The positive expression of LYVE-1 was found at the lymphatic vessels of normal and tumor tissues. There were no expression for E-cadherin and β-catenin on lymphatic vessels of normal and tumor tissue. However, β-catenin expressed in lymphatic vessels of gastric carcinoma weakly, and its expression degree had inverse correlation with the differentiation and metastasis of the tumor. Conclusions： LYVE-1 is a specific marker of the lymphatic vessel of the tumor tissue. Although playing some roles, the compound of E-cadherin/β-catenin is not an important element for the adhesion between tumor cell and lymphatic endothelial cell.
出处
《中国临床解剖学杂志》
CSCD
北大核心
2006年第2期170-172,共3页
Chinese Journal of Clinical Anatomy
基金
黑龙江省科技厅计划项目(GC03606-1)
