光动力治疗食道癌近期疗效观察

Effect of photodynamic therapy for esophageal carcinoma in near future

目的:探讨光动力学疗法(photodynamic therapy,PDT)对食道癌的治疗效果及其对患者生活质量的影响．方法:选用保守方法治疗的中晚期食管癌26 例,全部患者进行内镜下PDT．于治疗前及治疗后复查内镜并进行临床症状评定,并对患者采用世界卫生组织生活质量测定量表简表 (WHOQOL-BREF)进行调查,随访生活质量、生存时间,观察毒副作用．结果:光动力治疗后总有效率76．9％(20／26), 临床症状缓解率80．8％(21／26);半年生存率 73．1％(19／26)．与治疗前比较,患者PDT后3 mo 生理和心理领域的生活质量差异有显著性意义(F=4．807,P<0．05)．结论:PDT可显著改善食道癌患者的临床症状和生活质量,毒副反应小,耐受性好,是一种较好的治疗中晚期食道癌的有效手段．

AIM： To discuss the clinical efficacy and effect of photofrin photodynamic therapy （PDT） in treatment of patients with esophageal carcinoma. METHODS： Twenty-six esophageal carcinoma patients treated with conservative method were involved in this study. All patients were then treated with PDT under endoscope. Endoscopy was performed to determine the tumor response to PDT. The patients were followed up by WHOQOL-BREF to investigate the quality of life （QOL） and the survival time of patients as well as the side effect of PDT. RESULTS： The total rate of effective PDT was 76.9%（20/26）, and patients whose clinical symptoms alleviated covered a percentage of 80.8%（21/26）. The half-year survival rate for the patients was 73.1%（19/26）. The QOL of patients was significantly improved in physiological and psychological domains 3 mo after PDT （F= 4.827, P 〈 0.05）. CONCLUSION： PDT is effective and safe in the treatment of middleor late-stage esophageal carcinoma.