近年来流感病毒抗原性变异的比较

Comparative Study on Antigenicity Variation of Influenca Virus in Recent Years

目的了解流感病毒既往流行株与当前流行株抗原性变异的幅度.方法用2000年以来流行的与当前流行的A1、A3、B三株流感病毒株的标准抗原与免疫血清作交叉血凝抑制试验,根据所得数据计算抗原比,进行抗原性变异幅度分析.结果A1型2个流感病毒毒株间的抗原比为2.6;A3型4个流感病毒毒株间的抗原比为1.2～13.2;B型5个流感病毒毒株间的抗原比为1.8～22.6.结论自2000年以来,A1、A3型流感病毒抗原性变异幅度较小,B型流感病毒抗原性变异幅度较大.

Objective To study the antigenicity variation of influenza virus. Methods Perform cross hemagglutination inhibition test on the standard antigens of influenza virus strains A1 ,A3 and B epidemic since 2000 with the corresponding immunosera. Calculate the antigenic ratio using the obtained data and analyze the variation of antigenicity. Results The antigenic ratios of two A1 strains,four A3 strains and five B strains were 2.6,1.2-13.2 and 1.8-22.6 respectively. Conclusion Both A1 and A3 strains showed no significant variation in their antigenicties, however ,the antigenicity of B strain showed significant variation.