摘要
通过建立大鼠子宫内膜异位症(内异症)动物模型,观察小柴胡汤联合丹那唑治疗内异症的效果。利用免疫组化方法,观察各用药组在位、异位内膜环氧合酶-2(COX-2)表达的改变。结果显示,小柴胡汤组和联合用药组内异症大鼠异位内膜COX-2的表达水平明显低于其在位内膜,但丹那唑组和对照组则正好相反,异位内膜COX-2表达明显高于在位内膜,提示小柴胡汤治疗大鼠内异症的作用机制可能是通过下调异位内膜COX-2的表达,从而减少前列腺素的产生而实现的。
To explore the mechanism of Xiao Chaihu Tang in the treatment for endometriosis in rats,the rat model of endometriosis was established and were treated with Xiao Chaihu Tang , Danazol and Xiao Chaihu Tang plus Danazol for 4 weeks,respectively. Cyclooxygenase-2（COX- 2） expression in each group of endometrium and endometriotic tissue was observed by immuno- histochemistry method. The results showed that the expression of COX-2 in the endometriotic tissue was lower than that in endometrium in Xiao Chaihu Tang group and Xiao Chaihu Tang plus Danazol group, while Danazol group and control group were the opposite to Xiao Chaihu Tang group. The mechanism of Xiao Chaihu Tang in the treatment for endometriosis may be to decrease the COX-2 expression and reduce the formation of prostaglandins.
出处
《标记免疫分析与临床》
CAS
2006年第1期27-30,共4页
Labeled Immunoassays and Clinical Medicine
