抗环瓜氨酸肽抗体在类风湿关节炎诊断中的应用

Application of Anti-Cyclic Citrullinated Peptide Antibody Assay in the Diagnosis of Rheumatoid Arthritis

目的:了解抗环瓜氨酸肽(CCP)抗体在类风湿关节炎(RA)诊断中的意义。方法:用EL ISA方法检测121例RA患者,62例非RA的其他风湿病患者以及50例健康对照组中的抗CCP抗体。结果:121例RA患者中抗CCP抗体的阳性率为66.9%,在非RA的其他风湿病的阳性率是4.8%,健康对照组中的阳性率为0%。抗CCP抗体对RA的敏感性为66.9%,特异性为97.3%。抗CCP抗体阳性组与阴性组相比较,在C-反应蛋白(CRP)、血沉(ESR)和血小板(PLT)方面差异有显著性(P<0.05),抗CCP抗体与CRP、ESR、PLT之间存在相关性。结论:抗CCP抗体能用于RA,特别是早期RA的诊断,并且抗CCP抗体对RA的预后有一定的评估作用。

Objective： To understand the significance of the anti cyclic citrullinated peptide assayin the diagnosis of rheumatoid arthritis. Methods： The anti-CCP was detected in 121 patients with RA, 62 other rheumatisants and 50 healthy eontrolsby ELISA. Result： The positive rates were 66.9% in RA patients and 4.8% in other rheumatisants respectively. The sensitivity and specificity of Anti-CCP for RA were 66.9% and 97.3% respectively. The RA patients with Anti-CCP antibody were significantly different from the patients without antibody in CRP, ESR and PLT （P 〈 0.05）. Conclusion： Anti-CCP was very significant in the diagnosis of RA, especially early RA. It may possibly be of prognostic value for early RA.