摘要
以苯丙酮为起始原料，经溴化、Ｕｌｌｍａｎｎ缩合、重排、水解、合成非诺洛芬，再成钙盐，总收率４１．５％。亚探讨了Ｌｅｗｉｓ酸对重排的影响。
A mild and convenient preparation of fenoprofen calcium is disclosed. Propiophenone via bromination, Ullmann condensation, 1,2-aryl rearrangement hydrolysis and salt formation produced penoprofen calcium in 41.5% overall yield. It was found that, the quantity of I2 was reduced and reaction time was shortened notably by adding Lewis acid in the rearrangement step.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1996年第5期195-197,共3页
Chinese Journal of Pharmaceuticals
关键词
非诺洛芬
重排
相转移催化
合成
fenoprofen calcium, Ullmann reaction, rearrangement, phase transfer catalysis, synthesis
