CEA、CA_(19～9)、CA 50检测对胰腺癌诊断与分期的价值

Effectiveness of Multivariate Analysis of Tumor Markers in Diagnosis and Stage of Pancreatic Carcinoma

用 CEA、CA_(19～9)及 CA 50肿瘤标记物检测32例胰腺癌结果,诊断阳性率分别为93.5%、73.9%和52.9%。CEA 与 CA_(19～9)在胰腺癌分期中作用不大,而 CA_(19～9)如以95kU/L 为标准,转移组100%达到此值,而非转移组仅占阳性病例的57.1%,说明,如 CA_(19～9)>95kU/L,则提示胰腺癌相对已属晚期。

Preoperative serum levels of CEA,CA_(19～9) and /or CA50 were measured in 32 patients suspected of having pancreatic cancer.CEA was above the cut off levels of 10μg/L in 93.5% of patients, CA_(19～9) was above the cutoff limit of 30kU/L in 73.9% of patients and CA50 was above the cutoff li- mit of 20kU/L in 52.9% of patients.The positive result was obtained in 100% patients using the combination assay of CEA and CA_(19～9).Metastasis was proved in 72.2% patients whose CA_(19～9) was above 95kU/L.Our results suggest that combination assay of CEA and CA_(19～9) is reasonable in diagno- sis of pancreatic cancer,while CA_(19～9) 95kU/L suggest that tumors are advanced and resection is rarely possible.