中老年人血脂与血液流变学关系的研究

Study of Association Between Hemorheology and Surem Lipid in Middle—aged and aged persons

血液流变学检查559例中,女性:除胆固醇与纤维蛋白原呈正相关外,血脂与血液流变学指标无直线相关.男性:胆固醇与 RBC 压积、纤维蛋白原、高、低切全血粘度、低切还原粘度、血沉K值、RBC 电泳时间呈正相关;甘油三酶与高切全血枯度、高切还原粘度、纤维蛋白原呈正相关;胆固醇、甘油三酯与血浆粘度无直线相关,但胆固醇、甘油三酯的上4分位数组血浆粘度分别高于其下4分位数血浆粘度(P<0.01,P>0.05)。α—脂蛋白与全血粘度、还原粘度、血浆粘度、纤维蛋白原、RBC 压积及 RBC 电泳时间呈负相关。结果提示,高密度脂蛋白可改善血液流变学特性,是心血管疾病的保护因素.

We studied the relations between total cholesterol,triglyceride and α—lipoprotein on one hand and hemorheological variables on the other hand in 559 people aged over 40 years who were examined in a few hospital on Suzhou.The associations between serum-lipid and hemorheological variables in men were found to be defferent from those in women.The hemorheological variables were not found to be related to surum lipid except positive association between serum cholesteril and fibrinogen in women.In men,cholesterol was positively correlated to erythrocyte hematocrit,fibrinogen,blood viscosity at high and low-shear rates,whole blood reduced viscosity at low shear rate,erythrocyte sedimentation rate (ESR)K value and erythrocyte electropheresis time.For triglyceride,positive associations with blood viscosity at high shear rate,whole blood reduced viscosity at high shear rate and fibrinogen were ob- served.Plasma viscosity was significantly higher in upper quartile groups of cholesterol and triglyce- ride than in low quartile groups.α—lipoprotein have negative linear correlation to blood viscosity, whole blood reduced viscosity,plasma viscosity,fibrinogen,erythrocyte hematocrit and erythrocyte elec- tropheresis time.These results suggest that the α—lipoprotein contributes to improving flow property of blood and is a protective factor of cardivascular diseases.