摘要
目的探讨芸香苷(Ru)对实验性急性胰腺炎(AP)胰外多器官损伤的影响。方法牛磺胆酸钠(STC)逆行胆胰管注射诱发大鼠AP模型后,立即按Ru15、30、60mg/kg3个剂量持续静脉输注6h,观察AP大鼠多器官功能性指标,包括血清淀粉酶(AMS)、尿素氮(BUN)、肌酐(Cr)、谷丙转氨酶(ALT)、谷草转氨酶(AST)和乳酸脱氢酶(LDH)、动脉血气分析的变化。结果Ru15、30、60mg/kg3个给药剂量组可不同程度降低AP大鼠升高的AMS、BUN、Cr、ALT、AST、LDH。60mg/kg剂量组可升高AP大鼠降低的动脉PO2。结论静脉输注Ru对实验性AP胰外多器官功能损伤具有一定的保护作用。
Objective To investigate the effects of Rutoside （Ru） on multi-organ injury during experimental acute panereatitis （AP）. Methods The model of AP was induced by retrograde injection of Sodium Tauroeholate （STC） into bilipanereatie duct of rat. Ru （15,30,60mg/kg）was administered with intravenous infusion for 6 h immediately after the induction of AP. Some indicators which reflected the function of multi-organ of AP rats were observed, they were amylase （ AMS）, blood urea nitrogen （ BUN ）, ereatinine （ Cr）, alanine aminotransferase （ ALT）, aspartare aminotransferase （AST） ,lactic dehydrogenase （LDH） and indexes of blood gas analysis. Results Ru （ 15, 30, 60mg/kg）deereased AMS, BUN, Cr, ALT, AST and LDH, which had increased in AP rats. Ru （60 mg/kg） increased arterial PO2 in AP rats. Conclusion The study indicates that Ru administered by intravenous infusion exerts certain protective effects on multi-organ function injury in experimental AP rats.
出处
《安徽医科大学学报》
CAS
北大核心
2006年第2期150-153,共4页
Acta Universitatis Medicinalis Anhui
基金
安徽省自然科学基金资助项目(编号:01043907)
