法莫替丁大鼠肠吸收动力学的研究

Studies on the absorptive kinetics of famotidine in rat intestines

目的研究法莫替丁大鼠肠吸收的吸收动力学特征。方法采用大鼠离体和在体肠吸收模型,以高效液相色谱法测定法莫替丁的浓度。结果法莫替丁在肠道各部位的吸收速率按十二指肠、空肠、回肠、结肠的顺序下降,吸收速率常数分别为0.0500±0.0045、0.0435±0.0038、0.0410±0.0034、0.0252±0.0045/h。结论法莫替丁在肠道的吸收为被动扩散。

Objective To study the absorptive kinetics of famotidine in rat small intestines. Methods The intestinal absorption experiments were performed in situ and in vitro evaluation, in which the quantitative determination of famotidine was measured by a high-performance liquid chromatographic method. Results The permeability constants of famotidine was declined orderly from the duodenum, the jejunum, the ileum to the colon, and the permeability constants were 0. 050 0 ±0. 004 5,0. 043 5 ±0. 003 8,0. 041 0 ±0. 003 4,0. 025 2 ±0. 004 5/h,respectively. Conclusion Famotidine is passively absorbed by transferring the intestine.