原发性青光眼对角膜内皮细胞的影响

Effect of primary glaucoma on the corneal endothelium

目的 比较不同类型青光眼和正常人的角膜内皮细胞平均密度和六角型细胞百分比变化，探讨不同类型青光眼对角膜内皮细胞的影响。方法 选取60～75岁原发性青光眼患者，其中急性闭角型青光眼慢性期50眼，慢性闭角型青光眼96眼，开角型青光眼30眼，对照组为同年龄段的正常人378眼，测量记录角膜内皮细胞平均密度及六角型细胞百分比。测量数据用SPSSll．0进行统计学分析。结果 同年龄段急性闭角型青光眼慢性期较对照组统计学有极显著性差异（P〈0．01），慢性闭角型青光眼角膜内皮细胞平均密度较对照组统计学有显著性差异（P〈0．05），开角型青光眼患者角膜内皮细胞平均密度较对照组无显著性差异（P〉0．05），所有青光眼患者六角型细胞百分比较对照组均无显著性差异（P〉0．05）。结论 60～75岁急性闭角型青光眼慢性期、慢性闭角型青光眼患者的角膜内皮细胞平均密度较同年龄段的正常人下降，开角型青光眼患者角膜内皮细胞平均密度较正常人无明显变化，不同类型原发性青光眼对角膜内皮六角型细胞百分比无明显影响．

Objective To study the corneal endothelittm in patients with different subtypes of primary glaucoma as compared to normal control group and investigate effect of primary glaucoma on the corneal endothelium. Methods Corneal endothelittm cell density and percentage of hexagonal cells were measured in a series of primary glaucoma patients：50 eases with acute angle closure glaucoma （AACG）, 96 eases with chronic angle closure glaucoma （CACG）, 30 eases with chronic open angle glaucoma （COAG）, and 378 eases with controls matched for age（60-75 years old）. All data were analyzed statistically with SPSS 11.0. Results Corneal endothelltma cell density of AACG showed high significant differences（ P 〈 0.01 ） compared with controls, and its of CACG showed signifieant differences （P 〈 0. 05 ）, and its of COAG showed no significant differences too（ P 〉 0.05）. Percentage of hexagonal cells of all subtypes of primary glaucoma showed no significant differences（ P 〉 0.05） compared with controls. Conclusion Corneal endothelium of AACG and CACG patients is significantly different from the corneal endothelittm of the control group, and COAG shows no effect on the corneal endothelittm density. Percentage of hexagonal cells shows no change in all types of primary glaucoma.