紫杉醇对大鼠的一般生殖毒性作用

Reproductive toxicity studies of paclitaxel to rats prior to and in the early stages of pregrancy

紫杉醇是一种抗肿瘤新药，对大鼠的一般生殖毒性实验结果表明，给药剂量在１．０ｍｇ／ｋｇ时雄鼠和雌鼠摄食量减少，体重增长下降，雌鼠肾上腺及卵巢重量减轻，雄鼠的生育率和雌鼠受孕率下降，但对交配率无明显影响；母鼠剖检时发现黄体数、着床数及活胎数减少，着床痕数增加。未见致畸胎作用。对活胎体重、身长和尾长无明显影响。

Paclitaxel,an antineoplastic agent,was administered intravenously to rats daily at dose levels of 0(saline and vehicle),0.1,0.3 and 1.0 mg/kg for 63 days prior to mating and during the wating period in males ,and for 14 days prior to mating and during the mating period as well as day 0 to 7 of gestation in females. The results manifest that 1.0mg/kg Paclitaxel caused suppression of the body weight gains accompanied by the decreased food consumption in either male or female rats. Adrenal and ovarian weight were decreased in 1.0mg/kg dams at term. The fertility indices in both sexes of 1.0mg/kg were lower than the saline-treated group. However,the copulation indices in both sexes in 1.0 mg/kg rats were comparable to those of the saline-treated group.Decreases in the number of corpora lutea, implantations and live futuses or increases in the number fo empty implantation sits and total embryofetal deaths were observed in 1.0mg/kg dams. However, the fetal weights, crown-rump distances and tail lengths in live fetuses were not affected by paclitaxel treatment.