血浆sTM和sICAM-1在急性冠脉综合征患者中的表达

Study on the Expressions of Plasma Soluble Thrombomodulin and Soluble Intercellular Adhesion Molecule-1 in Acute Coronary Syndrome

目的:探讨血浆可溶性血栓调节蛋白(sTM)和可溶性细胞间黏附因子-1(sICAM-1)的水平在急性冠脉综合征患者(ACS组)发病中的作用。方法:用酶联免疫吸附法测定ACS组及对照组血浆sTM及sICAM-1的水平。结果:ACS组sTM水平低于对照组(P<0.01),其中AMI组sTM水平高于UAP组,但差异无统计学意义(P>0.05);sICAM-1水平AMI组高于对照组和UAP组(均P<0.01)。AMI组sTM与sICAM-1呈正相关(r=0.656,P<0.01),sTM及sICAM-1与肌钙蛋白I(TnI)呈正相关(r分别为0.453和0.34,均P<0.01)。结论:sTM、sICAM-1水平是反映ACS患者内皮细胞损伤程度和范围的良好标志。炎症反应、内皮损伤在ACS发生过程中起协同作用,炎症反应促进了急性血栓形成。

Objective： To study the effects Of plasma soluble thrombomodulin （sTM） and soluble intercellular adhesion molecule-1 （sICAM-1） levels in acute coronary syndrome （ACS） patients. Methods： The levels of sTM and sICAM-1 were examined by ELISA in ACS group and control group. Results： The level of sTM in AMI group was significantly lower than that in control group （P 〈 0.01）. The level of sTM in AMI group was higher than that in UAP group, and there was no significant difference between the two groups （P 〉 0.05）. The level of sICAM-1 in AMI group was significantly higher than those in control group and UAP group （P 〈 0.01）. The level of sTM was positive correlated with sICAM-1 in AMI group （r = 0.656, P 〈 0.01）. The levels of sTM and sICAM-1 were positive correlated with TnI in AMI group （r=0.453, r=0.342, P〈 0.01）. Conclusion： sTM and sICAM-1 can reflect the degree and extension of endothelial injury. Inflammation cooperates with endothelial injury in the process of ACS, and promotes the form of acute thrombosis.