咪哒普利对大鼠心肌梗死心室重构及MMPs的影响

Study on the Effect of Imidapril on Ventricular Remodeling and Matrix Metalloproteinases after Acute Myocardial Infarction in Rats

目的:评价咪哒普利对大鼠心肌梗死后8周心室重构和MMPs的影响。方法:冠状动脉左前降支结扎后24h,手术组大鼠被随机分至对照组(C组,n=10)、咪哒普利组(I组,n=10)。另设冠状动脉未结扎的大鼠为假手术组(SH组,n=10)。治疗后8周行超声心动图检查,心室称质量,明胶酶谱法测定左心室心肌组织MMPs的活性。结果:与SH组比较,手术组大鼠的相对左室质量(LVRW)、相对右室质量(RVRW)和左室舒张末内径(LVEDD)显著升高;与C组比较,I组可显著降低LVRW、RVRW和LVEDD。与SH组比较,C组的MMP-2活性显著升高;与C组比较,I组的MMP-2活性显著降低。结论:咪哒普利可抑制大鼠心肌梗死后8周MMP-2的活性,改善心室重构。

Objective： To evaluate the effect of imidapril on ventrieular remodeling and matrix metalloproteinases 8 weeks after acute myocardial infarction in rats. Methods： Operated rats were randomly separated into control group （group C, n=10） and imidapril group （group Ⅰ, n=10） 24 hours after anterior descending coronary ligation. The rats without operation were as sham-operated group （group SH, n =10）. Eight weeks after treatment, echocardiography and ventricular weighting were examined, and MMPs activity of left ventricular was measured by gelatin zymography. Results： LVRW, RVRW and LVEDD in operated groups increased significantly compared with those in group SH. LVRW, RVRW and LVEDD in group Ⅰ decreased significantly compared with that in group C. MMP-2 activity in group C increased significantly compared with that in group SH. MMP-2 activity in group Ⅰ decreased significantly compared with that in group C. Conclusion： MMP-2 activity can be inhibited by imidapril 8 weeks after acute myocardial infarction in rats, and improve ventricular remodeling is improved.