Bcl-2在非小细胞肺癌中的表达与临床病理特征的关系

The Relationship between the Expression of Bcl-2 and Clinical Pathology Characteristic

目的研究Bc l-2在人类非小细胞肺癌中的表达与临床病理特征的关系。方法应用免疫组织化学(S-P法)检测80例非小细胞肺癌组织标本和40例肺良性病变组织中Bc l-2的表达水平。结果非小细胞肺癌组织中Bc l-2表达水平(51.2%)显著高于肺良性病变组织(12.5%)(P<0.01);非小细胞肺癌组织中Bc l-2表达水平升高与肺癌组织学类型存在相关性(P<0.05)。结论Bc l-2表达升高与肺癌的发生、发展关系密切。

Objective To investigate the expression of Bcl -2 and the relationship between the expression and the clinical pathology characteristic in non -small cell lung cancer （NSCLC）. Methods The expression of Bcl -2 was detected in 80 NSCLC samples and 40 lung benign lesion tis- sues as control by immunohistochemistry（ S - P）. Results The expression level of Bcl - 2 was found to be significantly higher in NSCLC tissues than that in benign lesion tissues （ P 〈0.01 ） ;The expres- sion level of Bcl - 2 was closely related to histological classification in lung cancer patients （ P 〈 0.05 ）. Conclusion The increasing of Bcl -2 expression is may be related to the pathogenesis and development of lung cancer.