切除鼠肝70％致肝功能降低过程中RAAS与钠代谢的变化

The changes of RAAS and sodium metabolism in the process of hepatic functional decline induced with 70% hepatectomy in rats

切除鼠肝脏７０％导致肝功能降低，观察此过程中血浆肾素－血管紧张素－醛固酮系统（ＲＡＡＳ）活性变化及钠代谢的变化。结果，切除鼠肝脏７０％后第２天组，安基比林血浆半衰期（ＡＰｔ１／２）超过对照组４１．１％，术后第６天组ＡＰｔ１／２仍未恢复到对照组水平。术后第４天组ＲＡＡＳ活性仍显著高于对照组，ＡＰｔ１／２与血浆肾素活性（ＰＲＡ，ｒ＝０．８６４，Ｐ＜０．０１）。血管紧张素Ⅱ（ＡⅡ，ｒ＝０．６２９，Ｐ＜０．０１）呈显著正相关。伴随ＲＡＡＳ活性增强，术后２、３、４天三组的钠代谢均呈正平衡，第５天组达对照组水平，第６天组呈负平衡。实验结果提示：①肝功能只要恢复到一定程度，就可纠正钠潴留；

The changes of renin-angiotensin-aldosterone system(RAAS)and sodium metabolism were investigated in the process of hepatic functional decline induced by 70% hepatectomy in rats.The results showed that in the group at the second day after 70% hepatectomy,the half life time of antipyrine(APt1/2)was41.1% longer than that of control group and remained longer even in the sixth day after operation.In the 4th day after operation the RAAS activity was still higher than that of the control.There was marked positive corelationship between AP tl1/2 and plasma renin activity(PRA,r=0.864,P<0.01)and angiotensinⅡ(A,r=0.629,P<0.01).In accordance with the increase of RAAS activity,the sodium metabolist presented positive balance in the 2nd,3rd and 4th day groups after operation,the 5th day group was similar to the control and 6th day group showed negative.balance.These results indicated that 1.Sodium balance returned to normal so long as the hepatic function recovered to some extend;2.Sodium retention from hepatic dysfunction was at least partially mediated by RAAS.