摘要
目的观察表阿霉素(EPI)、甲酰四氢叶酸(CF)、5-氟尿嘧啶(5-Fu)顺铂(DDP)联合化疗治疗晚期胃癌的疗效和不良反应。方法应用EPI、CF、5-Fu和DDP(ECF)联合化疗治疗晚期胃癌36例,其中术后辅助性化疗14例,可评价疗效的有25例,全部病例均治疗2—6周期,观察评价疗效。结果完全缓解2例.部分缓解11例,总有效率52%。主要不良反应有骨髓抑制,脱发和厌食、恶心、呕吐等消化道反应,但惠者可耐受。结论ECF方案仍是治疗晚期胃癌较为有效的方案,不良反应可以耐受。
Objective To observe the efficacy and safety of combination chemotherapy of Epidoxorubicin ( EPI), Leucovorin ( CF), 5-Fluorouracil ( 5-Fu ) and Cisplation (DDP) for gastric cancer. Methods 36 cases of gastric cancer were treated with combination chemotherapy of EPI,CF,5-FU and DDP(ECF) at least 2 -6 cycles. Among them, 14 patients were in post -operation adjuvant chemotherapy another 25 patients were evaluable. Results The overall response rate was 52% (13/25) including 8% (2 cases) complete response (CR),partial reponse 11 cases,the adverse effects including gastrointestinal reaction such as narsea,vomiting,marrow depression and alopecin, etc. Conclusion The combination chemotherapy of EPI CF 5-FU and DDP (ECF) is effective and tolerable in the treatment for gastric cancer.
出处
《医药论坛杂志》
2006年第4期23-24,共2页
Journal of Medical Forum