慢性CO_2潴留大鼠肾脏带3蛋白的研究

The study of kidney band 3 protein in chronic carbon dioxide retention rats

本实验对ＣＯ＿２潴留２天和５天大鼠及慢性缺Ｏ＿２伴ＣＯ＿２潴留１月大鼠的肾皮质和髓质带３蛋白ｍＲＮＡ表达水平进行了研究。结果表明，慢性高碳酸血症大鼠肾皮质和髓质带３蛋白ｍＲＮＡ水平明显增加，这种适应性改变也许可提高肾集合管闰细胞基底面带３蛋白阴离子转运功能，使重吸收增加，以代偿体内的酸碱失衡。它可能在慢性呼吸性酸中毒时，肾脏酸碱调节中起重要作用。

Kidney band 3 protein mRNA expression in chronic hypoxic rats withhypercapnia and the rats with CO2 retention for 2 or 5 days was invest igated.The resultsshowed that relative contents of kidney band 3 p rotein in chronic hypoxic rats withhypercapnia and the rats with CO2 retention for 2 or 5 days were significantly increase thanthat of the control group(P< 0.01).These findings suggested that the levels of kidney band 3protein mRNA increased in chronic hypercapnia rats.This adaptation nught increase kidneyband 3 protein anion transportation function and aceelerate the rate of reabsorptionand compensate acid-base imbalanee,which could play an important role in renalacid-base regulation.