家兔热射病的实验研究

Experimental study n induced heat stroke in rabbits

将３４只清醒家兔热暴露，使直肠温度（ｒｅｃｔａｌｔｅｍｐｅｒａｔｕｒｅ，Ｔｒ）分别升至并保持在４２．０℃、４２．５℃、４３．０℃、４３．５℃和４３．５℃以上水平，研究在不同体温水平下热射病的发病规律。在达到预定体温后的８Ｏｍｉｎ内，Ｔｒ４２．０℃家兔无发病征象；Ｔｒ４２．５℃家兔半数发生休克并死亡；Ｔｒ４３．０℃和Ｔｒ４３．０℃以上家兔则全部发生休克并死亡。体温越高，发生休克的潜伏期和存活时间越短，但达到和超过Ｔｒ４３．５℃的家兔则无显著差别．休克家兔的血清Ｋ＋、ＧＯＴ、ＬＤＨ和ＣＰＫ明显升高。Ｔｒ高于４２．５℃家兔的脑皮质电图的波幅明显减小，呼吸频率由高峰值开始下降，显示脑损伤迹象。结果表明，Ｔｒ４２．５℃是家兔发生热射病的体温界限，Ｔｒ４３．０℃和Ｔｒ４３．５℃家兔可以用作研究热射病的动物模型。

In order to study the rule of pathogenesis of heat stroke,34 conscious rabbitswere exposed to heat environment to raise and mainta in their rectal temperature(Tr)at42.0℃ 42.5℃、43.0℃、43.5℃and over 43.5℃respectively.Within 180 min afterreaching the predeterminate levels, no signs of heat stroke was observed in rabbits with Tr42.0 ℃ ;half of the rabbits with Tr 42.5 ℃ and all with Tr 43.0℃or over Tr 43.0℃wentinto shock and eventually died.The fact that the higher the body temperature,theshorter the shock latency and survival time, was found between Tr 42.5℃and 43.5℃。The coneentrations df serum K+,glutamic oxaloaeetic transaminase,lactate dehydrogenaseand creatine phosphokinase were significantly increased in shock rabbits,The amplitude ofEC0G was obviously depressed,and the respiratory peak frequency started to decrease inthe rabbits whose Tr were over 42.5℃,showed sign of the brain damage. The results sug-gested that Tr 42.5℃is the critical level of body temperature to induce heat stro ke in rab-bits.The rabbits with Tr 43.0℃or Tr 43.5℃can be used as an animal model for theinvestigation of heat stroke.