冠心病患者SOD活性和血小板聚集性及心功能的相关性

Investigation of correlation of serum SOD activity with platelet aggregation and cardiac function in patients with coronary artery disease

为了解自由基在冠心病中的作用，观察了５０例冠心病患者血清ＳＯＤ活性的变化。结果显示心绞痛组患者ＳＯＤ活性显著下降，而ＭＤＡ含量明显升高（Ｐ＜０．０１），二者呈显著负相关（ｒ＝－０．４８，Ｐ＜０．００２），伴血小板聚集性增强（Ｐ＜０．０１），ＳＯＤ和血小板聚集性各项指标（Ｐｔｍａｘ、ＲｔＨ、ＰｔＫ）呈显著负相关（分别为ｒ＝－０．５２，Ｐ＜０．０１，ｒ＝－０．４１，Ｐ＜０．０５；ｒ＝－０．４０，Ｐ＜０．０５）．该组患者每搏输出量（ＳＶ）明显下降，射血前期／左室射血时间（ＰＥＰ／ＬＶＥＴ）升高（Ｐ＜０．０１），和ＳＯＤ分别呈显著正相关和负相关（ｒ＝０．５５，Ｐ＜０００５；ｒ＝－０．６１，Ｐ＜０．００１）．冠心病病情稳定期患者，ＭＤＡ升高但ＳＯＤ活性正常，二者呈极显著正相关（ｒ＝０．８３，Ｐ＜０．００１），ＳＶ和血小板聚集性均正常。

In order to study the clinical significanee of oxygen free radicals in the processof coronary artery disease,serum SOD(superoxide dismutase)activity was examined in 50cases with coronary artery disease. The results showed that(1) Serum SOD activity wasdecreased significantly while MDA(malondialdehyde)content was increased in 25 patients withangina pectoris as compared with 25 control subjects(P<0.01,P< 0.01,respectivily).SODactivity was negatively correlated with MDA content,Ptmax,PtH,PtK,and PEP/LVET(P< 0.02, P< 0.01, P< 0.05, P< 0.05,P<0.001,respectivily)while positively correlatedwith SV(P<0.005);(2)Serum MDA content was higher in 25 patients with stabile phaseof coronary artery disease than that of the healthy subjects(P<0.01 )and MDA contentwas positively correlated with SOD activity markedly(P<0.00 1).