白花前胡浸膏对肾型高血压大鼠左室肥厚的预防作用

Effects of Alcohol Extract of White-flower Hogfennel(Peucedanum praeruptorum) on Left Ventricular Hypertrophied Hypertensive Rats

用肾型高血压左室肥厚（LVH）大鼠模型，观察了白花前胡浸膏长期给药（ig0．2ml／100g体重·d，相当于0．6g生药／100g体重·d）对左室舒张功能，左室心肌线粒体和血管钙含量的影响，与假手术组相比，LVH组左室顺应性明显下降，左室心肌线粒体和尾动脉钙含量增加，与LVH组相比，白花前胡浸膏组的左室顺应性得到改善（P＜0．01），左心室肌线粒体及尾动脉钙含量较LVH组显著降低（P＜0．01），提示白花前胡浸膏具有钙桔抗作用。

In left ventricular hypertrophied hypertensive rats (LVH), effects of alcohol extract of Peucedanum praeruptorum(QHJG)on left ventricular(LV)compliance and Ca2+content in left ventricular myocardial mito chondria and tail artery were studied.QHJG 0.6g/100g(body weight).d was given for 9 weeks (ig). The LV compliance in LVH group was significantly decreased as compared with that in the sham-operated group. The Ca2+ content in left ventricular myocardial mitochondria and tail artery of LVH group was markedly raised. But QHJG could mardedly im prove the LV compliance and decrease the Ca2+ of left ventricular myocardial mitochondria and tissues of tail artery from LVH rats.These results suggest that QHJG can improve the LV compliance in LVH rats,which maybe related to its reduction of Ca2+ content of LV myocardial mitochondria and tissues of tail artery