聚(DL-乳酸-羟基乙酸)共聚物75／25中有机溶剂残留量的GC测定

Determination of residual organic solvents in poly-(DL-lactide-co-glycolide) -75/25

目的:测定聚(DL-乳酸-羟基乙酸)共聚物75／25中乙酸乙酯、二氯甲烷、乙醇的含量。方法:采用毛细管气相色谱法,色谱系统为:AC20色谱柱;柱温40℃;载气为氮气;检测器为FID;外标法计算含量。结果:在色谱条件下,测得各有机溶剂线性良好(r>0．99);平均回收率为99．3％～99．7％;RSD在0．15％～0．96％;最低检测限0．245～2．520μg·mL-1,3批样品中3种有机溶剂残留量符合要求。结论:该方法灵敏、准确、可靠。

Objective ：To determine the concentrations of residual ethyl acetate, ethanol, methylene dichloride in poly-（DL-lactide-co-glycolide）-75/25 （PLCG）. Methods：The quantification was con- ducted using a capillary gas chromatography consisted of a FID detector, the capillary column AC20 at 40 ℃ and nitrogen as a carrier gas. The residual solvent levels were monitored using an external standard method. Results：The concentrations of the three residual solvents showed appropriate linear curves （γ〉 0.99）. The average recovery was 99.3 % -99.7 % and the RSD was 0.15% -0.96%. The detection limit was 0. 245 - 2. 520μg· mL^-1. Conclusion： The reliable and simple GC method to determine the residual organic solvents was attainable.