摘要
麻醉开胸犬经12指肠给予莱葛冲剂8．5、17g／kg，30～45min后可见SBP、DBP、MAP，HR，LVSP，+dp／dtmax，和TPVR明显降低，约持续90～150min，而－dp／dtmax，LVEDP，CO，CI，SV，SI无明显改变。4．25g／kg对上述诸指标均无明显影响。提示莱葛冲剂对麻醉开胸犬具有明显降压作用，主要与其减慢心率，减弱心肌缩力及降低血管阻力有关。
Hemodynamic effects of Laigechongji (LGCJ)were studied in anesthetized open-chest dogs. LGCJ(in doseof 8. 5 and 17.0g/kg,id. )decreased significantly SBP, DBP, MAP, HR, LVSP, +dp/dt max and TPVR, 30~45 mins after medication,and continued for about 90~ 150mins. However,they had no significant effects ondp/dt max,LVEDP,CO,CI,SV and SI. These results suggest that LGCJ may cause hypotension,and its hypotensive effects may be related to its bradycardiac,negative inotropic and vascular resistance reducing activities.
出处
《中草药》
CAS
CSCD
北大核心
1996年第4期220-223,共4页
Chinese Traditional and Herbal Drugs
