CD_(44)v_6在卵巢上皮性肿瘤的表达及临床意义

Expression of CD_(44)v_6 in Ovarian Epithelial Neoplasms and it’s Clinical Signiificance

目的:通过研究CD44v6在卵巢上皮性肿瘤中的表达,探讨该指标与卵巢癌淋巴结转移的关系。方法:用免疫组化ElivisionTM法检测80例卵巢上皮性肿瘤中CD44v6的表达;运用图像分析系统对该指标进行定量检测。结果:①定性及半定量结果:CD44v6的表达呈递增趋势,组间有显著差异(P<0.05);②定量检测结果:CD44v6的表达,面积呈递增趋势,灰度呈递减趋势。结论:CD44v6表达升高,提示肿瘤进展,恶性度高,预后不良;计算机图像分析系统对卵巢上皮性肿瘤的自动化诊断、淋巴结转移及预后评估有重要意义。

Objective： Through the investigating the molecular expressions of CD44v6 in ovarian epithelial neoplasms, this study is trying to explore the relationship between the lymphatic spread of the tumor with the molecule. Methods： 80 cases were examined through ElivisionwM, an immune histochemistry method, for the expression of CD44vs in ovarian epithelial neoplasms. The system of image analysis was used to measure the expression of various molecules quantitatively. Results： ①Qualitative and semi - quantitative results：the expression of CD44v6 has upward tendency in that order and there is significant difference on the expression levels of CD44v6（ P 〈 0.05）. ②Quantitative examination result ： The total positive cell area of CD44v6 expression in the tumor has upward tendency in the order of benign, boundary and malignant cases, and the gray degree has downward tendency. Conclusion： Uprising expression of CD44v6 suggest the rapid development, high degree of malignancy and poor prognosis ; The study also shows the improtance of using the computer image analysis for automatic diagnosis of the ovarian epithelial neoplasms ,lymphatic metastases and its prognostic estimation.