抗氧化酶在肺癌病程中的动态观察及临床意义

Dynamic observation of blood antioxidases in patients with lung cancer and their clinical significance

为了分析抗氧化酶在肺癌病程中的变化规律及意义，本文测定了１８例肺癌患者外周血超氧化物歧化酶类（ＳＯＤｓ）、过氧化氢酶（ＣＡＴ）及谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活力和含量，并与１０例良性肺病相比较。结果显示：（１）肺癌组ＳＯＤ－Ａ、Ｍｎ－ＳＯＤ－Ａ及ＣｕＺｕ－ＳＯＤ－Ａ明显高于良性肺病组，ＣｕＺｎ－ＳＯＤ－Ｃ差异无显著性意义，ＳＯＤ－Ａ和Ｍｎ－ＳＯＤ－Ａ在术后呈明显降低；（２）ＣＡＴ活性在肺癌和良性肺病间无显著差异；（３）肺癌组ＧＳＨ－Ｐｘ活性明显低于良性肺病组，且随病程进展而逐渐降低。结果提示，抗氧化酶变化与肺癌的发生、发展可能有一定关系。

In order to analyse variation and significance of antioxdases in patients with lung cancer, the activity and content of SOD、Mn SOD、CuZn SOD、CAT、GSH Px in peripheral blood were determined in 18 patients with lung cancer and 10 patients with benign lung disease. The results showed that: (1)The SOD A、Mn SOD A、CuZn SOD A in lung cancer groups were significantly higher than that in the group of benign lung disease, however, the CuZn SOD Cushowed no significant difference, the SOD A and Mn SOD A were decreased after operation. (2)There was no marked difference of CAT activity between different groups. (3)The GSH Px activity was significantly lower in the lung cancer groups. The GSH Px activity decreased gradually in lung cancer patients from early to advanced stages. The results indicated that carcinogenesis and advanced lung cancer may relate to antioxidases. The measurement of Mn SOD A and GSH Px were useful in evaluating the effectiveness of treatment and prognosis.