姜黄素对小鼠血浆、脑及肝脏超氧化物歧化酶和脂质过氧化物含量的影响

Effects of curcumin on superoxide dismutase and lipid peroxide in mouse plasma, brain and liver

本文研究了姜黄素对小鼠血浆，脑及肝脏组织中超氧化物歧化酶（ＳＯＤ）活性和脂质过氧化产物丙二醛（ＭＤＡ）含量的影响。结果表明，姜黄素２０和４０ｍｇ／（ｋｇｄ）腹腔注射，７ｄ后小鼠血浆及脑组织的ＭＤＡ含量下降，血浆、脑及肝脏组织的ＳＯＤ活性均明显提高，呈现一定的剂量依赖关系。提示。

Curcumin is a yellow pigment extracted from plant Curcuma longa. the present study observed its effects on the activity of superoxide dismutase (SOD) and the level of lipid peroxidas in mouse plasma, brain and liver. The results showed that, when curcumin administered 20 and 40 mg/kg.d-1 intraperitoneally for seven days, the levels of malonaldehyde (MDA) in mouse plasma and brain were significantly decreased, and the activities of SOD in plasma, brain and liver were significantly increased. These effects were in a dose dependent manner. The results indicate that the antiperoxydant effect of curcumin may be partialy related to its enhancement on the acticity of SOD.