脱叶灵的合成工艺研究

Synthesis Method of Thidiazuron

以碳酸二甲酯、水合肼和氯乙醛等为原料,经过三步反应,制得关键中间体5-氨基-1,2,3-噻二唑,再与苯基异氰酸酯反应,合成了脱叶灵。通过实验研究,筛选了适合的溶剂和优化的反应条件,使产品总收率提高到18%,产品含量达到96%。本方法反应条件温和,三废减少,更适合于工业化生产。

In this article, three materials including dimethyl carbanate, hydrazine hydrate and chloroacetaldehyde were reacted into key intermediate 5-amino-1,2,3-thiadiazole. It reacted with phenyl isocyanate to get thidiazuron. From this test, suitable solvent and optimal reaction conditions were found, Under such conditions the yield reached 18% and purity of product 96%. The process enjoys advantages of mild reaction conditions, less waste and easier industrialization.