老年人轻度认知功能损伤危险因素的病例对照研究

A case-control study of risk factors in mild cognitive impairment

目的 探讨轻度认知功能损伤（MCI）的可能危险因素.方法 采用病例对照研究,分析MCI以及年龄、性别和职业相匹配的认知功能正常老年人各97例和143例.结果 单因素分析显示,冠心病、脑卒中和贫血病史以及受教育程度在两组之间差异有统计学意义;多因素分析去除了年龄的影响后,证实冠心病、脑卒中和贫血病史以及受教育程度与MCI显著相关,OR值（95%CI）分别为2.21（1.18～4.14）、2.18（1.20～3.98）、4.63（1.79～11.97）和0.75（0.58～0.97）.结论 冠心病、脑卒中和贫血病史可能是MCI的独立危险因素,高教育水平是MCI的保护因素.

Objective To explore the risk factors of mild cognitive impairment（MCI）. Methods A case-control study including 97 MCI patients and 143 cognitive normal controls（NC） in Chinese PLA General Hospital was conducted. The cases and controls were matched for age,gender and occupation. The relationship between MCI and various factors was analysed by univariate and multivariate analysis. Resnlts Results data from univariate analysis showed that the history of coronary heart diseases, stroke, anaemia, and the education level had significant differences between NC and MCI patients. Multivariate analysis confirmed that the history of coronary heart diseases, stroke, anaemia and the education level were significantly related to MCI and their ORs（95% confidence interval） were 2.21（1.18-4.14） ,2.18（1.20- 3.98）,4.63（1.79-11.97）,0.75（0.58-0.97）respectively. Conclusion The history of coronary heart diseases,stroke and anaemia were independent risk factors of MCI and high education level seemed to be a protective factor of MCI.