非ST段抬高急性冠脉综合征患者cTnI与冠状动脉病变的关系

Relation ship between Troponin I and coronary lesions of patients with Non-ST-segment elevation acute coronary syndrome

目的:探讨非ST段抬高急性冠脉综合征患者的心肌肌钙蛋白(ICardiacTroponinI,cTnI)水平与心电图ST段移位和冠脉病变的关系。方法:对92例非ST段抬高急性冠脉综合征患者于入院后12h内取静脉血用酶联免疫法测血清cTnI浓度,同时做12～18导联心电图,计算ST段缺血性下移程度,92例患者按Judkins法行冠脉造影术。依据cTnI>0.04ng/ml为阳性分为cTnI阳性组和cTnI阴性组。分析cTnI水平与ST段移位及冠状动脉病变之间的关系。结果:非ST段抬高的急性冠脉综合征患者的肌钙蛋白I阳性组ST段压低程度较阴性组明显(P<0.005)。血清cTnI阳性组的复杂病变和重度病变多于cTnI阴性组(P<0.01)。结论:非ST段抬高急性冠脉综合征患者的血TnI水平与ST段压低程度、冠脉病变稳定性及程度相关,血TnI水平的升高可作为识别冠状动脉不稳定病变评价的参考指标。

Objective：To observe the relationship between the cardiac troponin I （cTnI） and ST segments changes in electrocardiogram （ECG） and the narrowing characteristics of coronary artery in patients with Non-ST-segments elevation acute coronary syndrome. Methods： The cTn I in venous blood and the ECG were measured during 12 hours after the angina occurred . The ST segments depression were calculated.Patients underwent the coronary angiography were divided into cTnI positive groups and cTnI negetive groups. Results： Through the relative analysis, the degree of ST segments depression of cTnI positive groups were raised significantly compared with cTnI negetive groups, cTnI positive groups were more likely to be complex lesion and serious lesion. Conclusion： Serum levels of cTnI are correlated with the the degree of the ST-segment depression and the stability and extent of coronary lesions in patients with Non-ST-segment elevation acute coronary syndrome. The cTnI level is a useful marker for the identification of the unstable lesions of coronary artery.