系统性红斑狼疮患者肾损害与血清脂蛋白(a)水平相关性分析

The relationship between the serum lipoprotein(a) levels and nephric impairment in systemic lupus erythematosus

目的:研究系统性红斑狼疮患者血清脂蛋白(a)犤Lp(a)犦水平与其肾损害的相关性。方法:将48例狼疮肾炎患者根据24h尿蛋白定量(24hUpro)数值分为,<140mg组(A组)12例、140～500mg组(B组)16例和>500mg组(C组)20例,并与36例对照组比较。结果:B组和C组的血清Lp(a)较对照组升高,差异有显著性(P<0.01);而A组与对照组比较无统计学差异。B、C两组分别与A组比较,C组与B组比较,血清Lp(a)均升高,差异有显著性(P<0.01)。以Lp(a)为应变量,以24hUpro、TG、TC、HDL、LDL、Apo-A1、Apo-B为自变量,分别进行相关分析,结果表明,Lp(a)与24hUpro呈正相关(r=0.416,P<0.05),与其它血脂变化无明显相关性。结论:血清Lp(a)水平与系统性红斑狼疮患者的肾损害相关,Lp(a)水平随着肾损害的加重而升高。

Objective To analyze the relationship between the serum lipoprotein（a） levels and nephric impairment in systemic lupus erythematosus patients. Methods Forty-eight patients with lupus nephritis were selected and divided into three groups according to 24 hours urinary protein contents（24 h Upro） ： 〈 140 mg group （Group A, n = 12）, 140 - 500 mg group （Group B, n = 16） and 〉 500 mg group（Group C, n =20）, and thirty-six normal healthy subjects were recognized as control group. The levels of plasma lipoprotein（a）, apolipoprotein（Apo） and other lipids were measured respectively. Results Compared with the control group, the levels of triacylglycerol（TG）, low-density lipoprotein （LDL）, lipoprotein（a） in Group B and C were significantly increased （P 〈 0.01）, and there was no change in group A. The concentration of lipoprotein（a） in Group B and C was significantly higher than that in Group A. Moreover, the concentration of lipoproteln （a） in Group C was higher than that in Group B （P 〈 0. 01）. Lipoprotein （a） was positively correlated with the contents of 24 h Upro but not correlated with the contents of other lipids in plasma. Conclusion It is suggested that serum lipoprotein（a） level is positively correlated with nephrie impairment in SLE patients.