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类风湿关节炎患者体液中可溶性CD147的表达和意义 被引量:2

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摘要 目的:研究类风湿关节炎(RA)患者外周血、关节液中可溶性CD147(sCD147)的表达水平,探讨在RA致病中的作用,并以C反应蛋白(CRP)、血沉(ESR)作为病情活动指标,观察RA患者血清中可溶性CD147(sCD147)表达水平与病情活动的关系。方法:应用双抗体夹心ELISA检测37例RA患者外周血、12例RA患者关节液及16例健康人外周血、18例血清阴性脊柱关节病(SpA)患者外周血、8例SpA患者关节液中sCD147的表达水平;全自动乳胶免疫分析系统(日本三菱公司)检测患者的CRP;全自动血沉分析仪(DRAGONMED公司)测患者ESR。结果:RA患者血清中sCD147的含量高于健康对照组和SpA组;RA患者关节液中sCD147的含量明显高于SpA组。RA患者关节液中sCD147的含量明显高于其血清中的含量。RA患者血清中sCD147与CRP、ESR正相关。结论:RA患者血清、关节液中sCD147均可检出,且明显高于对照;RA患者关节液中sCD147明显高于其血清水平,提示sCD147可能参与RA关节损伤与发病。RA患者血清中sCD147表达水平与病情活动相关。
出处 《陕西医学杂志》 CAS 北大核心 2006年第4期394-397,共4页 Shaanxi Medical Journal
基金 *国家高技术研究发展(863)计划重点资助项目(No.2003AA215010)
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参考文献10

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同被引文献24

  • 1李鸿明,朱平,樊春梅,王彦宏,郑朝晖,李晓燕,卢宁.PMA对THP-1细胞和RA患者单核细胞及培养上清中CD147表达的影响[J].细胞与分子免疫学杂志,2006,22(3):333-335. 被引量:3
  • 2吴振彪,朱平,卢宁,史战国,樊春梅,王彦宏.CD147与类风湿关节炎成纤维样滑膜细胞MMPs合成的关系[J].第三军医大学学报,2006,28(13):1374-1377. 被引量:7
  • 3寿涛,李芹,林俊,郑红梅,张虹,毕丹艳,梅坚,和芳,严新民.类风湿关节炎发生动脉粥样硬化的机制研究[J].中华风湿病学杂志,2006,10(9):558-560. 被引量:31
  • 4王聪华,陈丽娜,朱平,樊春梅,王彦宏,贾俊峰.CD147分子通过VEGF促进类风湿关节炎滑膜组织中的血管新生[J].细胞与分子免疫学杂志,2007,23(5):426-428. 被引量:17
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  • 9Haug C, Leuz C, Diaz F, et al. Oxidized low-density lipoproreins stimulate extracellular malrix metalloproteinase inducer (EMMPRIN) release by coronary smooth muscle cells. Arterioseler Thromb Vase Biol, 2004, 24: 1823.
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