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磁场对急性胃损伤的治疗效应及其机制的实验研究 被引量:4

A Study on the Therapeutic Effects of Static Magnetic Fields on AcuteIndomethacin-induced Gastric Mocusal Injuries in Rats
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摘要 目的:探讨腹部恒磁场作用,对大鼠急性胃损伤模型的治疗效应及其作用机制。方法:10只健康SD大鼠,以indomethacin胃灌注法复制急性胃损伤模型,以表面磁强度为1300-1600GS,钡铁氧体恒磁场作用大鼠腹部3小时,观察胃损伤指数及病理损伤积分,同时对血浆中内皮素(endothelin,ET)、一氧化氮(nitricoxide,NO)、谷胱甘肽过氧化物酶(GSH-Px)及超氧化物岐化酶(SOD)水平进行比较。结果:恒磁场腹部作用后,大鼠胃损伤指数及病理损伤积分较对照组均显著减轻(p均<0.05);血浆ET-1和NO水平却无无明显改变(p均>0.05),血GSH-Px和SOD含量较对照组均明显升高(p均<0.05)。结论:腹部1300-1600GS恒磁场作用3小时,对大鼠急性胃损伤具有明显的治疗效应,磁场的这一效应可能与其增加血浆中清除氧自由基的GSH-Px和SOD活性有关。 Objective: To study the therapeutic effects and mechanism of static magnetic field exposure(SMFE) on the rats with acute indomethacin-induced gastric mocusal injuries. Methods: 20 healthy SD rats were randomly divided into two groups: magnetotherapy group(n= 10) and control group(n= 10), and then all the rats in the two groups were respectively given indomethacin(25mg/kg) by gastrogavage to make acute gastric injury models. The abdomines of the rats in magnetotherapt group were exposed to the static magnetic field of BaFel2019 with magnetic strength 1300 ~ 1600GS for 3 hotrrs, gastric injury index(GII), pathological diagnosis integral(PDI), the levels of endothehn(EF), nitric oxlde(NO), glutathione pemxidsse(GSH- Px) and superoxide dismutase(SOD) in the plasma of the rots were measured. Results: After tmdergoing SMFE, compared with control group, the G11 and PDI of the rots in magnetotherapy group were obviously lower(P〈 0.05); there was no significant difference in the levels of plasma ET and NO(P〉 0.05), but the levels of plasma GSH - Px and SOD were markedly higher(P〈 0. 05). Conclusion: 3 - hour exposure of static magnetic fields with magnetic strength 1300 ~ 1600GS lind significant therapeutic effects on the rats with acute gastric injuries induced by indomethaein. The therapeutic mechanism might relate to the increasing activation of plasma GStt - Px and SOD, which could clear oxygen free radicals in gastric tissues.
作者 丁立新
出处 《生物磁学》 2006年第1期50-52,共3页 Biomagnetism
关键词 恒磁场 大鼠 急性胃损伤 内皮素 一氧化氮 谷胱甘肽过氧化物酶 超氧化物岐化酶 Static magnetic field Rat Acute gastric injury ET NO GSH- Px SOD
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