孔结构不同的两种多孔羟基磷灰石陶瓷的性能比较研究

Study on the Property Comparison between Two Interconnected Porous Hroxyapatite Ceramics with Different Pore Structure

采用有机泡沫浸渍法和注浆成型法分别制备了网孔和球孔结构的羟基磷灰石多孔陶瓷;观察比较了2种多孔体的孔结构,系统地研究了2种孔结构的羟基磷灰石多孔体孔隙率和压缩强度的关系,并进行了体外模拟试验。结果表明:球形孔结构的HA多孔体有较好的抗压缩强度,其中,孔径为200 μm,孔隙率为65％的支架其压缩强度可达 8 MPa左右。体外模拟实验表明2种孔结构羟基磷灰石(HA)支架均有利于细胞的生长。

In the paper, two kinds of porous hydroxyapatite （HA） scaffolds with different pore structure were fabricated . The pore morphology, size and distribution of scaffolds were characterized using electron microscope. The compressive strength and good compatibleness by vitro cellular assay were tested. The result shows that the scaffolds with spherical macrospore have high compressive strength , among which the scaffold with the pore diameter of 200 μm and porosity of 65% has a compressive strength of 8 MPa. Both the porous biomaterials were proved to have a good compatible by vitro cellular assay. The osteoblast -like cells were attached and spread well throughout the two porous scaffolds.