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PTEN与胃癌的研究进展 被引量:2

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出处 《延安大学学报(医学科学版)》 2006年第1期7-8,共2页 Journal of Yan'an University:Medical Science Edition
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  • 3[1]Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH,Langford LA, Baumgard ML, Hattier T, Davis T, Frye C, Hu R,Swedlund B, Teng DH, Tavtigian SV. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 1997; 15:356-362
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  • 5[3]Li DM, Sun H. TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta. Cancer Res 1997; 57:2124-2129
  • 6[4]Cantley LC, Neel BG.New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci U S A 1999; 96: 4240-4245
  • 7[5]Wu X, Senechal K, Neshat MS, Whang YE, Sawyers CL. The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway. Proc Natl Acad Sci U S A 1998; 95:15587-15591
  • 8[6]Sun H, Lesche R, Li DM, Liliental J, Zhang H, Gao J, Gavrilova N, Mueller B, Liu X, Wu H. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,trisphosphate and Akt/protein kinase B signaling pathway.Proc Natl Acad Sci U S A 1999; 96:6199-6204
  • 9[7]Maehama T, Taylor GS, Dixon JE. PTEN and myotubularin: novel phosphoinositide phosphatases.Annu Rev Biochem 2001; 70: 247-279
  • 10[8]Besson A, Robbins SM, Yong VW. PTEN/MMAC1/TEP1 in signal transduction and tumorigenesis. Eur J Biochem 1999; 263: 605-611

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  • 2李锦毅,郑华川,杨琳,徐蕾,杨雪飞,高红,张荫昌,辛彦.胃癌中PTEN异常表达与围基因微卫星的杂合性缺失[J].中华肿瘤杂志,2004,26(7):389-392. 被引量:32
  • 3范凯,马坚妹,王朝晖,刘敏,李梅,许国旺,吕申.胃癌中hMLH1、hMSH2、PTEN和PCNA表达的相关性及意义[J].临床与实验病理学杂志,2006,22(2):236-237. 被引量:7
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