NP方案治疗晚期非小细胞肺癌的临床观察

Homemade vinorelbine based combination chemotherapy in non-small-call lung cancer

目的:观察长春瑞滨(NVB)加顺铂(DDP)联合化疗,治疗晚期非小细胞肺癌(NSCLC)的临床效果。方法:选择非小细胞肺癌58例,男42例、女16例,方案NVB 25 mg/m2,静滴d 1-8,DDP 20 mg/m2d 1-5静滴。结果:PR 28例、NC 27例、PD 3例,总有效率48.27%。主要毒副作用为骨髓抑制白细胞下降占81.03%,其中Ⅲ-Ⅳ白细胞下降率为36.21%,消化道反应发生率53.44%,大多数较轻,局部疼痛或静脉炎的发生率27.58%。结论:长春瑞滨(NVB)加顺铂联合化疗治疗晚期NSCLC有效率高,毒性反应可以耐受,值得临床研究应用。

Objective：To evaluate the results of combination chemotherapy with vinorelbine （NVB） plus cisplatin （DDP） in the treatment of non- small- cell lung cancer （NSCLC）. Methods：fifty -eight patients with advanced NSCLC were enrolled in this study. Adenocarcinoma was the most common type of malignancy. Results ： The overall rate was 48.27%. The does limiting toxicity was neutropenia, which was seen 81.03% in treated cases. The local venous toxicity was observed in 27.58% of the patients. Conclusions： A high response rate was obtained in advanced NSCLC treated by NVB plus DDP. NVB is a promising antitumor agent with tolerable toxicity.