慢支咳喘宁胶囊对实验性慢性支气管炎大鼠血清中IL-2、IL-8含量的影响

Effects of Manzhi Kechuanning Capsules on the contents of IL-2 and IL-8 in the blood serum of experimental rats with chronic bronchitis

目的:探讨慢支咳喘宁胶囊治疗慢性支气管炎的作用机制。方法:采用改良烟熏法复制慢性支气管炎大鼠模型,实验动物随机分为模型对照组、慢支咳喘宁胶囊低剂量组、慢支咳喘宁胶囊高剂量组、气管炎丸组及不加处理的空白对照组。造模各组以高、低剂量慢支咳喘宁胶囊、气管炎丸和生理盐水进行干预,测定各组大鼠血清中白细胞介素-2(IL-2)、白细胞介素-8(IL-8)的含量。结果:模型对照组大鼠血清中IL-2含量较空白对照组明显降低(P<0.01),而IL-8含量则较空白对照组明显升高(P<0.01);与模型对照组比较,治疗各组血清中IL-2含量明显升高(P<0.05或P<0.01),IL-8含量则明显降低(P<0.05或P<0.01)。结论:慢支咳喘宁胶囊可提高IL-2含量,降低IL-8含量,控制慢性炎症反应。

Objective： To investigate the internal mechanism on treating chronic bronchitis of Manzhi Kechualming Capsules. Methods： Duplicated the animal model of chronic bronchitis with refined smoking-fumigated method, the rats were randomly divided into model group, low dose group, high dose group, Qiguanyan Pills group and normal control group that didn＇ t treated. Made intervention with high and low dose Manzhi Kechuanning Capsules as well as Qiguanyan Pills（ another medicine of the similar kind） and 0.9 % NS, determined the contents of IL-2 and IL-8 in the serum. Results： The content of IL-2 in the serum of the model group was significantly decreased than that of the normal group（ P 〈0.01 ） ,but the content of IL-8 was significantly improved（ P 〈0.01 ）. Compared with the model group ,the content of IL-2 in the serum of each treating group was significantly improved reduced （ P 〈 0.05 or P 〈 0.01 ）, but IL-8 was opposite. Conclusion： Manzhi Kechuanning Capsules can control chronic inflammatory reaction by improving the content of IL-2 and reducing the content of IL-8.