摘要
目的研究布洛芬吡甲酯的合成。方法以布洛芬为起始原料,与氯化亚砜反应制成酰氯后与2-吡啶甲醇缩合,制得布洛芬吡甲酯。结果目标物的化学结构经IR1、HNMR1、3CNMR、MS及元素分析确证,总收率93.6%。结论改进后的合成方法反应条件温和,操作简便,易于放大制备。
OBJECTIVE To synthesize the Ibuprefen piconol.METHODS Ibuprefen piconol was prepared from Ibuprofen by reaction with thionyl chloride and then condensed with 2 - pyridinemethanol. RESULTS The chemical structure of target compound was confirmed by IR, ^1HNMR, ^13CNMR, MS and element analysis. The overall yield was about 93.6 %. CONCLUSION This method has the advantages of milder reaction condition, simpler work- up and higher yield. It can be applicable to large- scale preparation in industry.
出处
《华西药学杂志》
CAS
CSCD
北大核心
2006年第2期178-179,共2页
West China Journal of Pharmaceutical Sciences
关键词
布洛芬吡甲酯
非甾体抗炎药
布洛芬
2-吡啶甲醇
合成
Ibuprofen piconol
Nonsteroidal antiinflammatory drugs
Ibuprofen
2 - Pyridinemethanol
Preparation
