期刊文献+

酰氯法合成布洛芬吡甲酯工艺的改进 被引量:5

Improved synthesis of Ibuprofen piconol
下载PDF
导出
摘要 目的研究布洛芬吡甲酯的合成。方法以布洛芬为起始原料,与氯化亚砜反应制成酰氯后与2-吡啶甲醇缩合,制得布洛芬吡甲酯。结果目标物的化学结构经IR1、HNMR1、3CNMR、MS及元素分析确证,总收率93.6%。结论改进后的合成方法反应条件温和,操作简便,易于放大制备。 OBJECTIVE To synthesize the Ibuprefen piconol.METHODS Ibuprefen piconol was prepared from Ibuprofen by reaction with thionyl chloride and then condensed with 2 - pyridinemethanol. RESULTS The chemical structure of target compound was confirmed by IR, ^1HNMR, ^13CNMR, MS and element analysis. The overall yield was about 93.6 %. CONCLUSION This method has the advantages of milder reaction condition, simpler work- up and higher yield. It can be applicable to large- scale preparation in industry.
出处 《华西药学杂志》 CAS CSCD 北大核心 2006年第2期178-179,共2页 West China Journal of Pharmaceutical Sciences
关键词 布洛芬吡甲酯 非甾体抗炎药 布洛芬 2-吡啶甲醇 合成 Ibuprofen piconol Nonsteroidal antiinflammatory drugs Ibuprofen 2 - Pyridinemethanol Preparation
  • 相关文献

参考文献4

  • 1李以欣,郑绳一,蔡月刚,等.世界新药[M].北京:中国医药科技出版社,1987.209-210.
  • 2Noda K,Nakagawa A,Ishikura Y.Phenylacetic acid ester derivatives,GB.1573322[P].1975-12-24(CA 1978,88:120810c).
  • 3Noda K,Nakagawa A,Nakajima Y.Preparation of 2-(p-isobutylphenyl)propionic acid 2-pyridinemethyl ester[P].JP 8087770,1978-12-27(CA 1981,94:47150e).
  • 4Mercedes PV.Pyridylmethyl 2-arylpropionates[P].ES 526987,1983-11-03(CA 1986,105:60422k).

同被引文献81

引证文献5

二级引证文献18

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部