雷贝拉唑、阿莫西林和硫糖铝根除幽门螺杆菌的疗效观察

Triple therapy with Rabeprazole,Amoxicillin and Sucralfate for eradication of Helicobacter pylori in duodenal ulcer disease

目的观察雷贝拉唑、阿莫西林和硫糖铝三联疗法对根除幽门螺杆菌(HP)的疗效。方法将95例经胃镜检查确诊为十二指肠溃疡活动期,并经快速尿素酶试验和14C-尿素呼气试验,确定为HP阳性的患者分为两组。A组以雷贝拉唑0.01 g(qd),阿莫西林1 g(bid)和硫糖铝1 g(qid)治疗2周;B组以雷贝拉唑0.01 g(qd),阿莫西林1 g(bid)和克拉霉素0.5 g(bid)治疗2周。于用药结束后,第28天复查胃镜,观察溃疡愈合情况并检查HP。结果A组的HP根除率为91.5%,B组为93.8%,两组无显著性差异(P>0.05);A组溃疡的愈合率(93.6%)稍高于B组(89.6%),但无显著性差异(P>0.05)。结论雷贝拉唑、阿莫西林和硫糖铝三联疗法能有效地根除HP,溃疡愈合率高,安全且耐受性好,是一种较理想的HP根除新方案。

OBJECTIVE To evaluate a new triple therapy with Rabeprazole,Amoxicillin and Sucralfate for the eradication of Helicobacter pylori （HP） infection and the efficacy on healing of duodenal deer. METHODS 95 patients with active duodenal ulcer and HP infection proven by both rapid urease test and ^14C - urea breath test were randomly divided into 2 groups. Group A treated with Rabeprazole 0.01 g （qd） plus Amoxicillin 1 g （bid） and Sucralfate 1 g （qid） for two weeks. Group B treated with Rabeprazole 0.01 g （qd） plus Amoxicillin 1 g （bid） and Clarithromycin 0.5 g （bid） for two weeks. The eradication rates of liP and the healing rates of duodenal ulcer were evaluated by the second endoscopy and ^14C - urea breath test on the 28th day after completion of the treatment. RESULTS The eradication rates of HP in group A and group B were 91.5% and 93.8%, respectively. There was no statistically significant difference between the two groups（ P 〉 0.05）. Although the deer healing rates in group A（93.6% ）was higher than that in group B（89.6% ） ,there was no statistically significant difference between them （ P 〉 0.05）. CONCLUSION Two - week triple therapy with Rabeprazole, Amoxicillin and Sucralfate is highly effective, safe and well - tolerated treatment for eradication of HP infection.