酚酮类化合物三─O─乙酰基─β─D─吡喃葡萄糖醛酸甲酯的合成

Synthesis of Methyl (Tri - O - acetyl- β- D -glucopyranosid)Uronate of Tropolones

本文报导了酚酮（１ａ）以及３－乙酰基－、５－异丙基－、３－异丙烯基－、４－异丙基－、３－乙酰基－７－碘－和３－乙酰基－５．７－二澳－等取代的酚酮类化合物（１ｂ－ｇ）与２，３，４－三－Ｏ－乙酰基－α－Ｄ－吡喃葡萄糖醛酸甲酯澳代物（２）的Ｋｏｅｎｉｇｓ—Ｋｎｏｒｒ反应结果，以碳酸银为催化剂，８０℃下反应得到无取代以及７－乙酰基－、５－异丙基－、７－异丙烯基－、６－异丙基－、７－乙酰基－３－碘－和７－乙酰基－３，５－二澳－等取代的２－酮基三乙酰基吡喃葡萄糖醛酸甲酯．

The reactions of tropolone (la) and 3 - acetyl - .5 - isopropyl- .3 - isopropenyl-.4- isopropyl -. 3- acetyl - 7 - iodo - and 3- acetyl - 5,7 -dibromotropolones(1b ￣g) with methyl (tri- O-acetyl-α- D -glucopyranosyl bromide) uronate(2) were carried out in the presence of silver carbonate at 80℃ to give the unsubstituted and 7 - acetyl -.5 - iso- propyl-. 7 - isopropenyl -, 6 -isopropyl -. 7 - acetyl - 3 - iodo- and 7- acetyl 3,5 -dibromo -substituted 2 -troponyl triacetyl glucopyranosid uronate methyl esters.