口服利多卡因治疗围术期恶心呕吐60例

Lidocaine taken orally in treating 60 patients with perioperative nausea and vomiting

目的：观察利多卡因口服对围术期恶心呕吐的防治作用。方法：120例术中或术后发生恶心呕吐的上腹部手术病人,随机均分为甲氧氯普胺组和利多卡因组。病人发生恶心呕吐时,甲氧氯普胺组立即静脉注射甲氧氯普胺10 mg,利多卡因组给予2%利多卡因2～3 mL口服,记录2组起效时间及疗效。结果：甲氧氯普胺组起效时间为(2.2±s 1.2)min,利多卡因组(1.0±0.7)min,差异有非常显著意义(P＜0.01)。2组疗效亦有非常显著差异(P＜0.01)。结论：口服利多卡因治疗围术期恶心呕吐,作用迅速,安全有效。

AIM ： To observe the effect of lidocaine taken orally in treating and preventing patients with nausea and vomiting during or after operation. METHODS： One hundred and twenty patients with nausea and vomiting during or after upper abdomen operation were randomly divided into two groups. The patients in metoclopramide group were administered metoclopramide 10 mg intravenously and patients in lidocaine group were given lidocaine 2-3 mL orally as nausea or vomiting occurred. The time of onset and efficacy were recorded. RESULTS： The effective time of onset in lidocaine group was （1.0±s 0.7） min, obviously shorter than that of metoclopramide group （（2.2±1.2） min, P 〈 0.01 ）. There was also significant difference in clinical efficacy between the two groups （P 〈 0.01 ）. CONCLUSION ： Lidocaine taken orally in treating patients with nausea and vomiting during or after operation is a quick, safe and effective management.