西比灵治疗儿童偏头痛频繁发作的脑血流状态研究

EFFECT OF SIBELIUM ON CEREBRAL BLOOD FLOW FOR CHILDREN WITH FREQUENT MIGRAINE

目的:探讨西比灵治疗儿童偏头痛频繁发作的脑血流状态变化及临床意义。方法:应用经颅多普勒超声技术(TCD)研究50例儿童偏头痛频繁发作患儿服药前及服药2周后脑血流改变及头痛发作变化情况。结果:(1)30例一侧偏头痛患儿服药前头痛侧与非头痛侧大脑中动脉(MCA)、大脑前动脉(ACA)的收缩期峰值流速(Vs)有显著性差异(P<0.01),服药2周后双侧MCA、ACA的Vs无明显差异(P>0.05),非头痛侧服药前与服药2周后Vs无显著性差异(P>0.05);(2)20例双侧偏头痛患儿服药前与服药2周后的Vs有显著性差异(P<0.01)。结论:西比灵能明显改善偏头痛患儿的脑血流指标,可减少偏头痛的发作次数和头痛程度。

Objective： To study the effects of sibelium on cerebral blood flow for children with frequent migraine, and the clinical significance of sibelium in the treatment of children migraine. Methods ： Transcranial Doppler was carried out in 50 children with frequent migraine to evaluate the cerebral arterial systolic peak blood flow velocity （Vs） pre-and post-treatment with sibelium for 2 weeks. Results ： （ 1 ） Compared with the non-headache side, 30 patients of unilateral migraine showed significant difference （P 〈0.01 ） in Vs of middle cerebral artery （MCA） and anterior cerebral artery （ACA） on headache side pre-treatment, and showed no significant difference （ P 〉 0.05 ） after two-week treatments . There was no significant difference（P 〉0.05 ）of Vs on the non- headache side between pre- and post- treatment. （2） 20 patients of bilateral migraine showed significant difference （ P 〈 0.01 ） in Vs of MCA and ACA between pre- and post-treatment. Conclusion： Sibelium can profoundly improve the cerebral blood flow and effectively control symptoms of frequent migraine in children.