摘要
目的:观察唑来膦酸联合放射治疗对骨转移癌疼痛的疗效及不良反应。方法:98例骨转移癌患者随机分成观察组(51例)和对照组(47例)。观察组静滴唑来膦酸4 mg加局部放疗37.5GY/15F,之后再静滴唑来膦酸4 mg;对照组则单纯行放疗。结果:观察组与对照组止痛有效率分别为88.2%和74.5%(P>0.05),多发骨转移癌疼痛病灶研究组与对照组止痛有效率分别为86.5%和67.6%(P<0.05),随访2个月后观察组与对照组止痛有效率分别为86.3%和66.0%(P<0.05)。结论:唑来膦酸联合放射治疗骨转移癌疼痛疗效优于单纯放疗,唑来膦酸副作用轻。
Objective: To evaluate the efficacy of zoledronic acid combined with radiotherapy to relieve pain due to metastatic bone tumours. Methods: 98 patients with metastatic bone tumours were randomly divided into observation group (51 cases) and control group (47 cases). Observation group was treated with zoledronic acid (4 mg, i. v. ) and combined with radiotherapy ( DT 37.5GY/15F) ; control group was only treated by radiotherapy. Results: The effective rate of the observation group and control group was 88.2% and 74.5%, respectively ( P 〉 0.05 ). For multiple focus of bone metastasis tumour pain, the effective rate of observation group was 86.5% , while the control group was 67.6% (P 〈0.05) ; after two-month follow-up, the effective rate of the observation group and control group was 86.3% and 66. 0%, respectively (P 〈 0.05 ). Conclusion : Acid combined with radiotherapy is effective to relieve pain from metastatic bone tumours, and the side effect was mild.
出处
《中国疼痛医学杂志》
CAS
CSCD
北大核心
2006年第1期14-17,共4页
Chinese Journal of Pain Medicine
基金
温州市医药卫生科研项目(2005047)
关键词
唑来膦酸
放射治疗
骨转移癌
疼痛
Zoledronic acid
Radiotherapy
Metastatic bone tumour
Pain