淋巴细胞表面CCR5在HCV与HIV感染中表达

Expression of lymphocyte surface CCR5 in HCV and HIV infection

目的探讨T淋巴细胞表面C-C趋化因子受体5(CCR5)在丙型肝炎病毒(HCV)感染、人类免疫缺陷病毒(HIV)感染和HCV/HIV合并感染过程中的表达及意义。方法采用流式细胞术检测HCV感染组(n=21例),HIV感染组(n=14例),HCV/HIV感染组(n=28例)及正常对照组(n=30例)人外周血CD4+和CD8+T淋巴细胞表面CCR5的表达。结果与正常对照组相比,外周血CD4+和CD8+T淋巴细胞表面CCR5,HIV感染组高表达(P<0.01),HCV感染组和HCV/HIV合并感染组中低表达(P<0.01)。结论淋巴细胞表面CCR5的表达,HIV感染时升高、HCV感染时降低,HCV/HIV合并感染时HCV感染的作用更强。

Objective To investigate expression and significance of CC - chemokine receptor 5 （CCR5） in HCV mono - infection, HIV mono - infection and HCV/HIV co - infection, Methods The surface expression of CCR5 on CD4^＋ T cells and CD8^＋T cells from PBMC isolated from HCV infection（ n = 21 ）, HIV infection（ n = 14）, HCWHIV co- infection（ n = 28） and normal control（ n = 30） by flow cytometry. Results The expression of CCR5 on CD4^＋ and CD8^＋ T lymphocytes increased significandy in HIV mono- infection（P〈 0.01）, but decreased significandy both in HCV mono- infection and HCV/HIV co - infection（ P 〈 0.01）. Conclusion The surface expression of CCR5 on lymphocytes increased with HIV infection, decreased with HCV infection. In HCV/HIV oo- infection, HCV maybe effect on the expression of CCR5 on lymphocytes.