乙醛脱氢酶2基因多态性及环境暴露与胃癌易感性

Relationship between ALDH2 genetic polymorphisms and environmental exposure and susceptibility to gastric cancer

目的探讨乙醛脱氢酶2(ALDH2)基因多态性及环境暴露与胃癌易感性的关系。方法采用1:1配对病例-对照研究和扩增产物长度多态性(APLP)方法,检测南京市169例原发性胃癌患者和对照的ALDH2基因型,分析其在胃癌发生中的作用;结合环境危险因素分析,对ALDH2基因多态性与环境危险因素在胃癌发生中的交互作用进行分析。结果ALDH2基因型在病例组和对照组分布差异有统计学意义(χ2=4.617,P=0.032)。消化道疾病史、腌制食品、三餐不定时、暴饮暴食4项因素与胃癌发生的危险性增加有关;ALDH2基因与消化道疾病史、三餐不定时及暴饮暴食存在一定的交互作用。结论ALDH2基因多态性与胃癌易感性有关,并与环境暴露有一定的交互作用。

Objective To evaluate the association between（ALDH2）genetic polymorphisms and some risk factors and susceptibility to gastric cancer in Nanjing population. Methods PCR-Amplified product length polymorphism（PCR-APLP） technique were used to analyze the genetic polymorphisms of ALDH2 among 169 cases of gastric cancer and a control group of cancer-free and matched by age（ ± 5years）and sex. Each subject was asked to answer a questionnaire about epidemiology of gastric cancer and was phlebotomized to test association between the interaction of ALDH2 genetic polymorphisms and some risk factors and susceptibility to gastric cancer. Results There was significant difference of the frequency of ALDH2 genotypes between case group and control group（X^2 = 4. 617, P = 0. 032）. Cigarette smoking, bloat food, having meals indefintely, engorgement was significantily associated with gastric cancer susceptibility. Conclusion The genetic polymorphisms of ALDH2 might contribute to gastric cancer susceptibility and interact with environmental exposure.