慢性磷中毒患者尿中NAG活力动态变化分析

Analysis on dynamic changes of urine N-aceyl-β-D-aminoglycoside enzyme activities in patients with chronic phosphorus poisoning

目的探讨慢性磷中毒患者尿N-乙酰-β-D-氨基葡萄糖苷酶(NAG)活力动态变化及意义。方法用硝基酚比色法测定慢性磷中毒患者尿NAG活力并与正常对照组比较。结果慢性磷中毒患者中毒后第1年尿NAG与正常对照组比较差异无统计学意义(P>0.05);中毒后第2,3,4,5年均高于对照组,差异有统计学意义(P<0.01)。中毒越重,尿中NAG活力增高越明显。结论尿中NAG活力是慢性磷中毒患者肾损害的一项灵敏指标。

Objective To investigate the dynamic changes of urine N - aceyl - β- D- aminoglycoside enzyme（NAG） activityes in patients with chronic phosphorus poisoning and to understand the value of the changes. Methods Urine NAG activities were detected by nitroxylphenol in both patient group and control group and data were analyzed between two groups. Results No significant difference on urine NAG activities（ P 〉 0.05）was found between patient group and control group in the first year after phosphorus poisoning, while in the second to fifth year respectively, the urine NAG activities were all significantly higher in the patient group than those in the control group （P〈 0.01）. Conclusion Urine NAG activity plays an important role in judging the kidney damage of patients with chronic phosphorus poisoning and is a sensitive factor in diagnositics of chronic phosphorus poisoning.