乐脉颗粒治疗急性脑梗死的临床观察

The Effect of Lemai Granule(乐脉颗粒) on Acute Cerebral Infarction

目的：探讨乐脉颗粒治疗急性脑梗死的临床疗效及作用机理。方法；选发病在1周以内的急性脑梗死患者102例，随机分为乐脉颗粒治疗组51例和血栓通注射液对照组51例进行临床对照观察。应用比色法测定血清脂质过氧化物（LPO）和超氧化物歧化酶（SOD）。单向免疫法测定载脂脚蛋白A1（apoA1）和载脂蛋白B100（apoB100）。检测脑血流动力学和血液流变学指标，观察治疗前后变化。结果：治疗组总有效率为88．2％（95％CI=79．3％～97．1％），对照组总有效率为68．6％（95％CI=55．9％～81．3％）。两组综合疗效比、较，有显著性差异（u=27429，P=0．0079）。乐脉颗粒能使患者血清LPO、apoB100水平明显降低，同时升高血清SOD、apoA1水平。血液流变学的全血还原黏度和脑血流动力学指标也有明显改善，与对照组治疗后比较，差异有显著性（P均〈0.01）。结论：乐脉颗粒较对照药物治疗脑梗死疗效为佳，其收益为0R=0．29（95％CI=0．10～0．82）。NNT=5（95％CI=2．8～27．4）；对血液流变学和血流动力学参数有明显改善作用。抗脂质过氧化损伤和调节载脂蛋白代谢可能是其重要的作用机理。

Objective： To observe the effect of Lemai Granule （LG） on acute cerebral infarction and investigate the mechanism of LG. Methods ：102 cases with acute cerebral infarction were divided randomly into the treatment group（51 cases） and the control group （51 cases）. The treatment group were treated with LG and the control group were treated with Xueshuangtong Injection （血栓通注射液）. Serum LPO, SOD,apoA1 ,apoB100and indexes of hemorheology and hemodynamics were determined. Result：The level of serum LPO and apoB100 were reduced,Serum SOD and apoAlwere raised and the indexes of hemorheology and hemodynamics were improved. The differences weresignificant （P 〈 0. 01）. Conclusion：LG improved hemorheology and hemodynamics and treated acute cerebral infarction effectively.