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细胞周期蛋白依赖性激酶活化激酶(CAK)的研究进展 被引量：6

Advances in the studies of cyclin dependent kinase-activating kinase (CAK)
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摘要 细胞周期蛋白依赖性激酶(CDKs)的基本功能是对细胞周期进行调控。CDKs的激活需要与特异性亚基cyclins结合,并被CDK7-cyclinH-MAT1三元复合物(CAK)磷酸化。此外,CDK7-cylinH-MAT1还是转录因子ⅡH(TFⅡH)的亚基组成部分,磷酸化RNA聚合酶Ⅱ(RNAPⅡ)大亚基的羧基末端结构域(CTD)。CAK因为在细胞周期过程中的重要作用,而受到越来越广泛的关注。本文主要就CAK自身活性调节及其对细胞周期的调控进展作一综述。 Cell cycle progression is regulated by cyclin dependent kinases （CDKs）. The activity of CDKs is tightly controlled by several mechanisms, including binding of subunits to CDKs （cyclins）, and phosphorylation by CDK7-cyclin H-MAT1（CAK）. Besides, CAK complex is a component of transcription factor Ⅱ （TF Ⅱ H） and phosphorylates the carboxy-terminal domain （CTD） of the largest subunit of RNA polymerase Ⅱ （RNAP Ⅱ）. Because of pivotal function of CAK in cell cycle, broad attention has arisen, This review focuses on the regulation of CAK activity via its＇ three subunits and its regulation on the cell cycle progression.
作者 储琳 钱旻 严缘昌
机构地区 华东师范大学生命科学学院 中国科学院上海生命科学研究院生物化学与细胞生物学研究所
出处 《生命科学》 CSCD 2006年第2期127-132,共6页 Chinese Bulletin of Life Sciences
基金 上海市教育委员会E-研究院建设计划项目资助(E03003)
关键词 CAK CDK CTD 磷酸化 CAK CDK CTD phosphorylation
分类号 Q253 [生物学—细胞生物学] Q555.7 [生物学—生物化学]
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  • 1Fesquet D,Labbe J C,Derancourt J,et al.The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues.EMBOJ,1993,12 (8):3111～3121.
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生命科学
2006年 第2期

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